… glycine
(Glycine) amino sour, also known for non-essential amino acids. Name Abbreviations: Gly amino mordant glycine namely the maximum simple kin framework, the body of a non-essential amino acids in the particle either acidic and basic functional groups, for a lusty electrolyte in aqueous solution, the solubility in polar solvents extra elementary insoluble non-polar solvents, yet likewise has a higher boiling point and thawing point, aqueous solution pH via the norm of glycine tin present different molecular fashions.
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glycine composition and ecology of the physiological role of glycine? Glycine synthesis? Drug analysis uses food grade pharmaceutical grade glycine Glycine Glycine industrial grade feed grade glycine updated 2010 edition of Chinese Pharmacopoeia revised combination and content of glycine nature of the English name Glycine: Aminoacetic acid
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alias amino acid formula C2H5NO2 products use non-toxic fertilizer for decarbonization, medicine and pesticide toxicity CAS No. 56-40-6 conservation is non-toxic , non-corrosive. Packaging and storing used plastic bags, polypropylene woven jackets, sacks or circular barrel bag, 25kg. Stored in a cool dry place. As a general chemicals provides arsenal and transportation. Physical Properties White monoclinic or hexagonal crystals or white crystalline powder. Odorless, has a special sweetness. The respective density of 1.1607. Melting point 248 ℃ (decomposition). pK’1 (COOH) is 2.34, pK’2 (N + H3) 9.60. Soluble in water, solubility in water: 25 ℃ when 25g/100ml; 50 ℃ when 39.1g/100ml; 75 ℃ when 54.4g/100ml; 100 ℃ when 67.2g/100ml. Extremely complicated to dissolve in ethanol, 100g ethanol dissolved about 0.06g. Almost insoluble in acetone and ether. Hydrochloride and hydrochloric acid reaction. pH (50g / L solution, 25 ℃) = 5.8 ~ 6.4 weight quality standards HGB 3075-79 75.07 Structure NH2CH2COOH consumption norms of raw materials consumed appoint specifications, kg / t 1, 95% chloroacetic acid method ammonia Industrial 880 1600 Hexamine 98% 350 ethanol 95% 1100 2, Strecker method of formaldehyde sodium cyanide 70% 70% 114 70% 1020 Barium chloride 930 80% 1430 725 90% sulfuric acid glycine has a peerless sweet taste, can ease acid, alkaline taste, add the food to cover up the bitterness and enhance the sweet taste of saccharin. If the body of extravagant intake of glycine, not merely can not be sponged at the body, and would crash the equilibrium of the body’s absorption of amino acids influence the absorption of other amino acids, leading to nutritional imbalance and health. Glycine as the main raw material in the creation of breast drinks on youth human and babies of regular growth and evolution is possible to result in adverse effects. Physiological role of glycine? In the chief nervous system, especially in the backbone, the glycine is an inhibitory neurotransmitter. If glycine receptors are refreshed, chloride ions through the recipient into the nerve cells leading to inhibitory postsynaptic potentials. Strychnine is the opponent of these ion receptors. In mice the LD50 concordance of 0.96 mg / kg body weight, cause of necrosis was over excitability. In the central nervous system is the same agonists glycine and glutamate. Glycine synthesis? Formaldehyde, hydrogen cyanide and water can be synthesized glycine:
? Drug analysis means name: Glycine API – Determination of glycine – non-aqueous titration Application: This method uses titration glycine materials drug in the glycine content. This method is suitable as glycine API. Principle of the method: the test of anhydrous formic acid dissolved, increase glacial acetic acid, according apt potentiometric titration, titration with perchloric acid droplets, and the results of titration with blank test correction, according to the quantity of titrant accustomed to count the glycine content. Reagents: 1. Acetic acid 2. Anhydrous formic acid 3. Perchloric acid titration solution (0.1mol / L) 4. Crystal violet arrow solution 5 benchmark of potassium hydrogen phthalate Equipment: Sample preparation: 1. Perchloric acid titration solution (0.1mol / L) preparation: anhydrous acetic acid (water content calculated by each 1g of water and acetic anhydride 5.22mL) 750mL, adding perchloric acid (70 ~ 72%) 8.5mL, shake, put chilly, add suitable amount of anhydrous acetic acid to make into a 1000mL, shake, for 24 hours. If the measured test cozy to acetylation, shall be determined with a moisture content of the liquid water content, water and acetic anhydride and then accommodated to the liquid water content of 0.01% to 0.2%. Calibration: Take dried at 105 ℃ to constant weight root of potassium hydrogen phthalate of approximately 0.16g, accurately weighed, add 20mL of anhydrous acetic acid to liquefy, add 1 drip of crystal violet indicatall butlution, titrate slowly with the liquid to blue, and the results of titration experiments with empty amendment. Each 1mL perchloric acid titration solution (0.1mol / L) is equivalent to 20.42mg of potassium hydrogen phthalate. According to the expense of liquid potassium hydrogen phthalate and the amount taken, calculate the concentration of the solution. (2) crystal violet crystal violet indicatall butlution to take 0.5g, add glacial acetic acid 100mL dissolve. Procedure: Weigh the test precision of about 70mg, add 1.5mL of anhydrous formic acid to dissolve, add glacial acetic acid 25mL, according to potentiometric titration with perchloric acid titration solution (0.1mol / L) titration, and titration results with the blank test alteration. Each 1mL perchloric acid titration solution (0.1mol / L) is equivalent to 7.507mg of C2H5NO2. Note: References: The Chinese Pharmacopoeia, National Formulary Committees, Chemical Industry Press, 2005 version, a, p.70. Use edible grade glycine 1 is used as flavoring agents, sweeteners, and DL-alanine, citrate, etc. with the use of alcohol-containing drinks; synthetic wine and excellent correction of fared secondhand as acid agent, buffer; in salted pickles, sweet sauce, soy sauce, vinegar and fruit juice used as additives to improve food flavor, savor and retain flavor, provided the source and so sweet; 2 for surimi products, peanut butter and additional preservatives, can inhibit the circulation of Bacillus subtilis and Escherichia coli; 3 using its own amino and carboxyl, salt and vinegar flavor, for a dampening effect; 4 as feed additives in the attractant (attractant); 5 food brewing, meat processing and soft drinks formula and saccharin sodium to the bitter agent; 6 as butter, cheese, margarine, immediate noodles, wheat flour and lard and other stabilizers; 7 for food processing aboard vitamin C to stabilize; 8 in 10% of MSG in the ingredients as glycine; 9 can be used as preservatives, anti-corrosion activity one essential role. Pharmaceutical grade glycine 1 for Medical Microbiology and biochemistry of amino acid metabolism of drugs; 2 for chlortetracycline buffer anti-Parkinson’s disease drug L-Dopa vitamin B6 , and the synthesis of threonine and other amino acids raw materials; 3 for amino acid nutrition infusion; 4 for cephalosporin raw materials; thiamphenicol intermediates; imidazole acetic acid synthesis intermediates, etc.; 5 as raw materials for cosmetics. Primarily as feed-grade glycine poultry, caress food, primarily livestock feed additives and additional amino acid attractants. As hydrolyzed protein cumulative, hydrolyzed protein as a synergist. Industrial grade glycine as pesticide intermediates, such as the herbicide glyphosate as the cardinal raw material; plating bath additives; PH regulator [Packing]: Food Grade: kraft paper sack, net weight 25KG. Pharmaceutical Grade: cardboard drum, net weight 25KG. Feed grade and industrial grade: woven bag, net weight 25KG. [Transportation]: Handle gently to avert discharging marred packaging, anti-sun and rain, can no be noxious, harmful substances with the transport. [Storage]: Store in a chilly dry place. Reagent grade glycine 1 for peptide synthesis, as amino acids protect the monomer; 2 for the arrangement of tissue mores middling, copper, gold and silver test; 3 for glycine with amino and carboxyl zwitterionic, and therefore a strong buffer, commonly used in the preparation buffer. Revised edition of Chinese Pharmacopoeia 2010 update of glycine Gan’ansuan Glycine page number: 2005 Edition 2 -70 [Amendment] [Properties] white to off-white crystalline powder; odorless, sweet. This product is soluble in water, in ethanol alternatively ether about insoluble. Content resolve to take this product is about 70mg, accurately weighed, add 1.5ml of anhydrous formic acid to dissolve, add glacial acetic acid 50ml, according to potentiometric titration (Annex Ⅶ A), titration with perchloric acid solution (0.1mol / L) titration, and the results of titration experiments with blank correction. Each 1ml perchloric acid titration solution (0.1mol / L) is equivalent to 7.507mg of C2H5NO2. [Updated] [identification] (1) of this product with glycine fitting reference standards, respectively, dissolved and diluted with water containing about 10mg per 1ml of solution, as the test solution and reference solution. According to other amino acids below the chromatographic conditions for the test, the test solution was the cardinal spots of color and place should be the main spots with the same reference solution. [Check] to take the product of other amino acids, dissolved and diluted with water containing about 10mg per 1ml of solution, as the test solution; accurate amount of amount of test solution, diluted with water is made containing about 0.05mg per 1ml of solution, as the control solution. In dissimilar reference substance, the amount of glycine and alanine, set in the same phial, dissolved in water and diluted to 1ml, respectively, each containing about 10mg, and 0.05mg of mixed criterion solutions. According to TLC (Appendix Ⅴ B) experiment, accurate drawing of the three kinds of solution, 2μl, respectively, points above the same silica gel G TLC panel, n-propanol – ammonia (7:3) as the agent, started by about 10cm, dry, dried at 80 ℃ for 30 minutes, sprayed with ninhydrin in n-propanol solution (1 → 100), heated at 105 ℃ to spot color, and instantly outlook. Control solution was one manifest spot to be merged criterion solutions should be explicitly explicit detachment of two spots, the test solution in adding to spots outdoor the main spot was the number of impurities must no surpass 1, the color of the main spots with the control solution compared not deeper (0.5%). Open Category: medicine, pharmacology, absorbent system drugs, Biochemistry and Molecular Biology, antacids and treatment of peptic ulcer disease, narcotic me to amend the